Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.35 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12128255 | 0.80 | DHFR (0.42) | DHFRMAPTKDM4EAPPRAPGEF4 | |
| SCHEMBL16411600 | 0.77 | MAPT (0.48) | DHFRMAPTKDM4ENPC1RAB9A | |
| SCHEMBL16943552 | 0.76 | DHFR (0.38) | DHFRMAPTKDM4EAPPRAPGEF4 | |
| SCHEMBL30720083 | 0.71 | NCF1 (0.44) | MAPTMAOB | |
| SCHEMBL30720085 | 0.71 | NCF1 (0.44) | MAPTMAOB | |
| SCHEMBL12128397 | 0.70 | APP (0.53) | DHFRMAPTKDM4EAPPNPC1 | |
| SCHEMBL18354324 | 0.70 | DHFR (0.40) | DHFRMAPTKDM4EAPPHPGD | |
| SCHEMBL16943529 | 0.70 | DHFR (0.40) | DHFRMAPTKDM4EAPPHPGD | |
| SCHEMBL12129676 | 0.69 | APP (0.55) | DHFRAPPAURKAAURKBJAK2 | |
| SCHEMBL12128973 | 0.69 | APP (0.52) | DHFRMAPTKDM4EAPPRAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |