Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23064560 | 0.88 | NPC1 (0.48) | TP53SMN1; SMN2ALDH1A1GAANCEH1 | |
| SCHEMBL20626906 | 0.86 | ALDH1A1 (0.46) | TP53SMN1; SMN2ALDH1A1GAANCEH1 | |
| SCHEMBL829712 | 0.83 | KMT2A (0.45) | TP53SMN1; SMN2ALDH1A1GAAHPGD | |
| SCHEMBL23064553 | 0.80 | TP53 (0.45) | TP53SMN1; SMN2ALDH1A1GAANCEH1 | |
| SCHEMBL829466 | 0.80 | SMN1; SMN2 (0.65) | TP53SMN1; SMN2ALDH1A1GAANCEH1 | |
| SCHEMBL829196 | 0.79 | SMN1; SMN2 (0.63) | TP53SMN1; SMN2ALDH1A1GAANCEH1 | |
| SCHEMBL19614565 | 0.77 | RBP4 (0.44) | TP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL829640 | 0.77 | GAA (0.64) | TP53SMN1; SMN2ALDH1A1GAANCEH1 | |
| SCHEMBL21089037 | 0.76 | TP53 (0.51) | TP53SMN1; SMN2ALDH1A1GAANCEH1 | |
| SCHEMBL28217739 | 0.76 | NPC1 (0.62) | TP53SMN1; SMN2ALDH1A1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495359-A1 | FLAP MODULATORS | Janssen Pharmaceutica NV (BE) | 2019-06-12 | — | — | EP | disclosed |