Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.60 |
| ▸ | DHFR | P00374 | 2/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12128866 | 0.76 | APP (0.81) | APPDHFRKDM4EMAPTTRPA1 | |
| SCHEMBL12129574 | 0.75 | APP (1.00) | APPDHFRROCK2 | |
| SCHEMBL17805809 | 0.75 | APP (0.75) | APPDHFRRAPGEF4CYP3A4 | |
| SCHEMBL21089220 | 0.75 | APP (0.75) | APPCYP3A4 | |
| SCHEMBL12128973 | 0.74 | APP (0.52) | APPDHFRRAPGEF4ROCK2CYP3A4 | |
| SCHEMBL16943024 | 0.69 | MAPT (0.52) | APPMAPT | |
| SCHEMBL7922469 | 0.66 | ADORA2A (0.53) | KDM4E | |
| SCHEMBL29699563 | 0.65 | DHFR (0.41) | APPDHFRRAPGEF4KDM4EMAPT | |
| SCHEMBL21088595 | 0.65 | DHFR (0.46) | APPDHFRRAPGEF4KDM4EMAPT | |
| SCHEMBL2119807 | 0.65 | SOS1 (0.61) | APPDHFRRAPGEF4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |