Guaietolin

Guaietolin

SCHEMBL2108931

CCOc1ccccc1OCC(O)CO

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.74
LMNA P02545 2/20 0.74
AGTR1 P30556 1/20 0.74
KDM4E B2RXH2 3/20 0.69
ALOX15 P16050 2/20 0.68
MEN1 O00255 1/20 0.60
CYP2C19 P33261 1/20 0.60
KMT2A Q03164 1/20 0.60
L3MBTL1 Q9Y468 2/20 0.49
GLA P06280 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.47
TSHR P16473 1/20 0.47
MAPK1 P28482 1/20 0.47
ALDH1A1 P00352 1/20 0.46
ADRB2 P07550 2/20 0.45
ADRB1 P08588 2/20 0.45
MAPT P10636 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31474676 0.90 ALOX15 (0.74) CYP1A2LMNAAGTR1KDM4EALOX15
SCHEMBL26326254 0.90 CYP1A2 (0.81) CYP1A2LMNAAGTR1KDM4EALOX15
SCHEMBL15677621 0.87 ALOX15 (0.70) CYP1A2LMNAAGTR1KDM4EALOX15
Guaifenesin SCHEMBL31161209 0.85 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4EALOX15
Guaifenesin SCHEMBL4321 0.85 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4EALOX15
Guaifenesin SCHEMBL4322 0.85 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4EALOX15
Guaifenesin SCHEMBL29759010 0.85 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4EALOX15
Guaifenesin SCHEMBL160234 0.85 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4EALOX15
SCHEMBL11711802 0.84 ALOX15 (0.66) CYP1A2LMNAAGTR1KDM4EALOX15
Guaifenesin SCHEMBL2459821 0.84 CYP1A2 (0.96) CYP1A2LMNAAGTR1KDM4EALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3003285-B1 SOLID PHARMACEUTICAL DOSAGE FORM FOR RELEASE OF AT LEAST TWO ACTIVE PHARMACEUTICAL INGREDIENTS IN THE ORAL CAVITY MCNEIL AB (SE) 2022-02-16 EP claimed
EP-3003285-A1 SOLID PHARMACEUTICAL DOSAGE FORM FOR RELEASE OF AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT IN THE ORAL CAVITY McNeil AB (SE) 2016-04-13 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
WO-2014196916-A1 SOLID PHARMACEUTICAL DOSAGE FORM FOR RELEASE OF AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT IN THE ORAL CAVITY MCNEIL AB (SE) 2014-12-11 WO claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
EP-3003285-B1 SOLID PHARMACEUTICAL DOSAGE FORM FOR RELEASE OF AT LEAST TWO ACTIVE PHARMACEUTICAL INGREDIENTS IN THE ORAL CAVITY MCNEIL AB (SE) 2022-02-16 EP disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10877035-B2 Advanced drug development and manufacturing ICAGEN, LLC (US) 2020-12-29 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
US-5273993-A Antiarthritic agents; osteoporosis A. H. ROBINS COMPANY, INCORPORATED (US) 1993-12-28 US disclosed
US-5194446-A Antiarthritic agents A. H. ROBINS COMPANY, INCORPORATED (US) 1993-03-16 US disclosed
US-5192785-A Sulfamates as antiglaucoma agents A. H. ROBINS COMPANY, INCORPORATED (US) 1993-03-09 US disclosed
US-5025031-A Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants A. H. ROBINS CO., INC. (US) 1991-06-18 US disclosed
EP-0403185-A2 Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals A.H. ROBINS COMPANY, INCORPORATED (US) 1990-12-19 EP disclosed