Guaifenesin

Guaifenesin

SCHEMBL29759010

COc1ccccc1OCC(O)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 1.00
LMNA P02545 3/20 1.00
AGTR1 P30556 1/20 1.00
KDM4E B2RXH2 4/20 0.69
SMN1; SMN2 Q16637 3/20 0.64
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
CYP2C19 P33261 1/20 0.60
TSHR P16473 3/20 0.56
MAPK1 P28482 1/20 0.56
IDO1 P14902 1/20 0.54
ALDH1A1 P00352 1/20 0.54
HPGD P15428 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
MAPT P10636 1/20 0.51
CASR P41180 1/20 0.50
ALOX15 P16050 1/20 0.50
THRB P10828 1/20 0.49
HTT P42858 1/20 0.49
POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guaifenesin SCHEMBL31161209 1.00 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
Guaifenesin SCHEMBL160234 1.00 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
Guaifenesin SCHEMBL4322 1.00 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
Guaifenesin SCHEMBL4321 1.00 CYP1A2 (1.00) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
Guaifenesin SCHEMBL4894727 0.98 CYP1A2 (0.96) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
Guaifenesin SCHEMBL2459821 0.98 CYP1A2 (0.96) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
Guaifenesin SCHEMBL28898302 0.92 CYP1A2 (0.84) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
Guaifenesin SCHEMBL28062894 0.92 CYP1A2 (0.84) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
SCHEMBL29941729 0.90 LMNA (0.82) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2
SCHEMBL2328960 0.90 LMNA (0.82) CYP1A2LMNAAGTR1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119998352-A Epoxy resin curing agent, epoxy resin composition, sealing material, electrically conductive material, thermally conductive material, adhesive for camera module, adhesive for structure, matrix resin for fiber-reinforced plastic, impregnating and fixing material, interlayer insulating film, film-type solder resist, sealing sheet, electrically conductive film, anisotropic electrically conductive film, thermally conductive film, and method for producing dyed cured product 旭化成株式会社 2025-05-13 CN claimed
WO-2025084921-A1 DEVELOPMENT OF FORMULATIONS FOR THE MANAGEMENT AND ANTIVIRAL, IMMUNOMODULATORY AND ANTI-INFLAMMATORY TREATMENT OF THE NEW SARS-COV-2 INFECTION AND THE ASSOCIATED DISEASE, COVID-19, AND ITS VARIANTS, FORMULATED FROM GLYCYRRHIZIC ACID SALT AND THE DERIVATIVES THEREOF DRAGUSTINOVIS MARIA ESTHER (MX) 2025-04-24 WO claimed
CN-112029717-B Serum-free in vitro domestication culture of human mesenchymal stem cells 深圳博雅感知药业有限公司 2023-11-03 CN claimed
CN-119998352-A Epoxy resin curing agent, epoxy resin composition, sealing material, electrically conductive material, thermally conductive material, adhesive for camera module, adhesive for structure, matrix resin for fiber-reinforced plastic, impregnating and fixing material, interlayer insulating film, film-type solder resist, sealing sheet, electrically conductive film, anisotropic electrically conductive film, thermally conductive film, and method for producing dyed cured product 旭化成株式会社 2025-05-13 CN disclosed
EP-4547220-A1 A STABLE ORAL LIQUID COMPOSITION COMPRISING TERBUTALINE & GUAIFENESIN Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi (TR) 2025-05-07 EP disclosed
WO-2025084921-A1 DEVELOPMENT OF FORMULATIONS FOR THE MANAGEMENT AND ANTIVIRAL, IMMUNOMODULATORY AND ANTI-INFLAMMATORY TREATMENT OF THE NEW SARS-COV-2 INFECTION AND THE ASSOCIATED DISEASE, COVID-19, AND ITS VARIANTS, FORMULATED FROM GLYCYRRHIZIC ACID SALT AND THE DERIVATIVES THEREOF DRAGUSTINOVIS MARIA ESTHER (MX) 2025-04-24 WO disclosed
US-20240382417-A1 Compositions Comprising Guaifenesin and Eriodictyol SYMRISE AG (DE) 2024-11-21 US disclosed
CN-118084633-A Purification method of guaifenesin 开封明仁药业有限公司 2024-05-28 CN disclosed
CN-117580888-A Epoxy resin composition, film, method for producing film, and cured product 旭化成株式会社 2024-02-20 CN disclosed
WO-2024005758-A1 A STABLE ORAL LIQUID COMPOSITION COMPRISING TERBUTALINE & GUAIFENESIN ABDI IBRAHIM ILAC SANAYI VE TICARET ANONIM SIRKETI (TR) 2024-01-04 WO disclosed
CN-112029717-B Serum-free in vitro domestication culture of human mesenchymal stem cells 深圳博雅感知药业有限公司 2023-11-03 CN disclosed
CN-116615509-A Epoxy resin composition, adhesive film, printed circuit board, semiconductor chip package, semiconductor device, and method for using adhesive film 旭化成株式会社 2023-08-18 CN disclosed
CN-115725055-A Epoxy resin composition 旭化成株式会社 2023-03-03 CN disclosed
CN-115043811-A Preparation method of 4- [ (2-methoxyphenoxy) methyl ] -1, 3-dioxolane-2-one 苏州敬业医药化工有限公司 2022-09-13 CN disclosed
WO-2022138343-A1 EPOXY RESIN COMPOSITION, ADHESIVE FILM, PRINTED WIRING BOARD, SEMICONDUCTOR CHIP PACKAGE, SEMICONDUCTOR DEVICE, AND METHOD FOR USING ADHESIVE FILM 旭化成株式会社 2022-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240382417-A1 Compositions Comprising Guaifenesin and Eriodictyol ERLIN1, TAS2R38, TAS2R39 CYP1A2 570/4885LMNA 2050/4885AGTR1 2130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.