Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NCK1 | P16333 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21089939 | 0.82 | MEN1 (0.37) | ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL22699619 | 0.81 | MEN1 (0.34) | CYP1A2ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL21055029 | 0.75 | MEN1 (0.36) | ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL22699635 | 0.74 | EPHX2 (0.55) | CYP1A2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL15691803 | 0.72 | UHRF1 (0.35) | ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL22743534 | 0.71 | ALDH1A1 (0.42) | CYP1A2ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL12002288 | 0.70 | MEN1 (0.39) | ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL10226483 | 0.70 | PDE3B (0.33) | ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL19751453 | 0.70 | GAA (0.55) | CYP1A2ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL31318567 | 0.70 | GAA (0.55) | CYP1A2ALDH1A1GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019112719-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2019-06-13 | — | — | WO | disclosed |