Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18464548 | 1.00 | HIF1A (0.38) | HIF1AHSD17B10NOS2NOS3NOS1 | |
| SCHEMBL22779403 | 0.83 | HIF1A (0.37) | HIF1AHSD17B10NOS2NOS3NOS1 | |
| SCHEMBL25964107 | 0.83 | HIF1A (0.37) | HIF1AHSD17B10NOS2NOS3NOS1 | |
| SCHEMBL4360524 | 0.81 | SLC6A2 (0.39) | HIF1AHSD17B10SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25972536 | 0.81 | SLC6A2 (0.39) | HIF1AHSD17B10SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19407944 | 0.81 | HIF1A (0.36) | HIF1AHSD17B10NOS2NOS3NOS1 | |
| SCHEMBL18735919 | 0.80 | — | — | |
| SCHEMBL4308213 | 0.79 | — | — | |
| SCHEMBL1132940 | 0.79 | — | — | |
| SCHEMBL16165636 | 0.78 | SLC6A3 (0.35) | HIF1AHSD17B10NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177357-A1 | ASYMMETRIC AUXILIARY GROUP | WAVE LIFE SCIENCES JAPAN (JP) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177357-A1 | ASYMMETRIC AUXILIARY GROUP | NIT2, IDH1, HBG2 | HIF1A 1548/4885HSD17B10 169/4885NOS2 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.