SCHEMBL21090302

SCHEMBL21090302

C=Cc1cccc2c1CC(=O)C2=O

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.42
CES1 P23141 1/20 0.42
TYR P14679 6/20 0.34
CYP19A1 P11511 4/20 0.33
ALDH1A1 P00352 2/20 0.33
MIF P14174 2/20 0.33
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MAOA P21397 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2236020 0.76 NR3C2 (0.45) ALDH1A1KDM4EGAAMAPTMAOA
SCHEMBL11740121 0.73 CYP2A6 (0.44) ALDH1A1KDM4EMAPTMAOA
SCHEMBL21090481 0.72 MAPT (0.47) BCHECES1ALDH1A1MIFKDM4E
SCHEMBL1245608 0.72 PNMT (0.49) BCHECES1ALDH1A1MIFKDM4E
SCHEMBL1512573 0.71 ACHE (0.47) BCHECES1TYRALDH1A1MAOA
SCHEMBL21090301 0.70 BCHE (0.42) BCHECES1ALDH1A1MIFKDM4E
SCHEMBL13979626 0.68 CYP1A2 (0.46) ALDH1A1MIF
SCHEMBL16569613 0.68 CYP19A1 (0.56) BCHECES1TYRCYP19A1ALDH1A1
SCHEMBL5951929 0.67 ACHE (0.60) CYP19A1
SCHEMBL22734366 0.66 MAPT (0.38) ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3720597-B1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES STICHTING TECHNISCHE WETENSCHAPPEN (NL) 2023-11-29 EP claimed
US-11612877-B2 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-03-28 US claimed
US-20200368721-A1 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2020-11-26 US claimed
US-12318756-B2 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof UNIVERSITEIT UTRECHT HOLDING B.V. (NL) 2025-06-03 US disclosed
EP-3720597-B1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES STICHTING TECHNISCHE WETENSCHAPPEN (NL) 2023-11-29 EP disclosed
EP-3720597-B1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES STICHTING TECHNISCHE WETENSCHAPPEN (NL) 2023-11-29 EP disclosed
US-20230201799-A1 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-06-29 US disclosed
US-20230201799-A1 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-06-29 US disclosed
US-11612877-B2 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-03-28 US disclosed
US-20200368721-A1 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2020-11-26 US disclosed
WO-2019110557-A1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2019-06-13 WO disclosed