Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 9/20 | 0.40 |
| ▸ | FEN1 | P39748 | 9/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21055860 | 0.78 | GRM5 (0.41) | GRM5ALDH1A1MAPTALOX5APFEN1 | |
| SCHEMBL21089746 | 0.76 | GRM5 (0.42) | GRM5ALDH1A1MAPTHPGDALOX5AP | |
| SCHEMBL22743879 | 0.75 | ALDH1A1 (0.39) | GRM5ALDH1A1MAPTGLAHPGD | |
| SCHEMBL28145540 | 0.75 | GRM5 (0.44) | GRM5ALDH1A1MAPTALOX5APFEN1 | |
| SCHEMBL9098370 | 0.75 | RAB9A (0.43) | GRM5ALDH1A1MAPTGLAHPGD | |
| SCHEMBL14852740 | 0.74 | MAPT (0.45) | GRM5ALDH1A1MAPTGLAHPGD | |
| SCHEMBL28891610 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPTGLAHPGDACHE | |
| SCHEMBL4795864 | 0.71 | ALDH1A1 (0.45) | GRM5ALDH1A1MAPTGLAHPGD | |
| SCHEMBL22509833 | 0.71 | CYP11B1 (0.45) | ALDH1A1MAPTGLAHPGDACHE | |
| SCHEMBL5332952 | 0.70 | GRM5 (0.48) | GRM5MAPTALOX5APFEN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019112719-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2019-06-13 | — | — | WO | disclosed |