Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14852740 | 0.89 | MAPT (0.45) | RAB9AMEN1KMT2AGFERMAPT | |
| SCHEMBL4119102 | 0.80 | NNMT (0.40) | RAB9AMEN1KMT2AGFERMAPT | |
| SCHEMBL22743534 | 0.79 | ALDH1A1 (0.42) | RAB9AMEN1KMT2AGFERALDH1A1 | |
| SCHEMBL22743004 | 0.79 | BACE1 (0.39) | RAB9AMEN1KMT2AGFERACHE | |
| SCHEMBL22717228 | 0.78 | NNMT (0.35) | RAB9AMEN1KMT2AGFERMAPT | |
| SCHEMBL30626361 | 0.76 | KMT2A (0.41) | RAB9AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL22743872 | 0.75 | UHRF1 (0.36) | RAB9AMEN1KMT2AGFERITGB3 | |
| SCHEMBL21090747 | 0.75 | GRM5 (0.51) | RAB9AMEN1KMT2AGFERMAPT | |
| SCHEMBL22742636 | 0.74 | EHMT2 (0.33) | RAB9AMEN1KMT2AGFERNNMT | |
| SCHEMBL6307293 | 0.73 | MEN1 (0.43) | RAB9AMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069961-B | Method for preparing tetrahydrobenzo [ b ] [1,8] naphthyridine compound | 中国科学院大连化学物理研究所 | 2020-04-21 | — | — | CN | claimed |
| US-5484921-A | Process for preparing benzo[b]naphthyridines | LABORATOIRE ROGER BELLON (FR) | 1996-01-16 | — | — | US | claimed |
| CN-108069961-B | Method for preparing tetrahydrobenzo [ b ] [1,8] naphthyridine compound | 中国科学院大连化学物理研究所 | 2020-04-21 | — | — | CN | disclosed |
| CN-108069961-B | Method for preparing tetrahydrobenzo [ b ] [1,8] naphthyridine compound | 中国科学院大连化学物理研究所 | 2020-04-21 | — | — | CN | disclosed |
| CN-108069961-B | Method for preparing tetrahydrobenzo [ b ] [1,8] naphthyridine compound | 中国科学院大连化学物理研究所 | 2020-04-21 | — | — | CN | disclosed |
| US-5484921-A | Process for preparing benzo[b]naphthyridines | LABORATOIRE ROGER BELLON (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5442070-A | Derivatives of fluoro-quinoline carboxylic-3-acid and preparation therefor | LABORATOIRE ROGER BELLON (FR) | 1995-08-15 | — | — | US | disclosed |
| EP-0538101-A1 | Process for the preparation of benzo(b)naphthyridines | LABORATOIRE ROGER BELLON (FR) | 1993-04-21 | — | — | EP | disclosed |