Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 8/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21091006 | 0.83 | KMT2A (0.36) | KMT2AMPOCYP3A4PDE1APDE1B | |
| SCHEMBL18367714 | 0.82 | KMT2A (0.42) | KMT2AMPOCYP3A4PDE1APDE1B | |
| SCHEMBL19589424 | 0.73 | MPO (0.46) | KMT2AMPOCYP3A4JAK2JAK1 | |
| SCHEMBL18713633 | 0.73 | KMT2A (0.46) | KMT2APDE1APDE1BPDE1CJAK2 | |
| SCHEMBL18378772 | 0.72 | KMT2A (0.47) | KMT2AMPOCYP3A4JAK2JAK1 | |
| SCHEMBL6312157 | 0.69 | KMT2A (0.44) | KMT2AMPOCYP3A4ADRA1DADRA1A | |
| SCHEMBL17194964 | 0.67 | KMT2A (0.42) | KMT2AMPOCYP3A4ADRA1DADRA1A | |
| SCHEMBL5754567 | 0.67 | APLNR (0.45) | KMT2AMPOCYP3A4JAK2GRM5 | |
| SCHEMBL18415121 | 0.67 | TYK2 (0.40) | KMT2AJAK1TYK2GRM5GRM1 | |
| SCHEMBL29767299 | 0.65 | KMT2A (0.55) | KMT2ACYP3A4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495358-A1 | AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | Bristol-Myers Squibb Company (US) | 2019-06-12 | — | — | EP | disclosed |