Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095492 | 0.85 | KMT2A (0.55) | KMT2ACASP6KEAP1NT5EADRA1D | |
| SCHEMBL16963173 | 0.84 | AR (0.41) | KMT2ACASP6MPOCYP3A4KEAP1 | |
| Hydrochloric Acid SCHEMBL30549511 | 0.83 | KMT2A (0.53) | KMT2ACASP6KEAP1NT5EADRA1D | |
| SCHEMBL18378772 | 0.81 | KMT2A (0.47) | KMT2ATRPA1ATMMPOCYP3A4 | |
| SCHEMBL16964095 | 0.81 | KMT2A (0.43) | KMT2ACASP6KEAP1NT5EADRA1D | |
| SCHEMBL3319361 | 0.77 | KMT2A (0.40) | KMT2ACASP6KEAP1 | |
| SCHEMBL19589424 | 0.76 | MPO (0.46) | KMT2ACASP6MPOCYP3A4KEAP1 | |
| SCHEMBL18367714 | 0.76 | KMT2A (0.42) | KMT2ACASP6MPOCYP3A4KEAP1 | |
| SCHEMBL5754567 | 0.76 | APLNR (0.45) | KMT2AMPOCYP3A4KEAP1TSHR | |
| SCHEMBL17194964 | 0.76 | KMT2A (0.42) | KMT2ACASP6MPOCYP3A4KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043300-A1 | Piperazine derivatives | PFIZER INC. | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043300-A1 | Piperazine derivatives | CD4, CCR5, RRP15 | KMT2A 2921/4885TRPA1 419/4885ATM 4814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.