Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | CASR | P41180 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | GPR65 | Q8IYL9 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16849226 | 0.84 | SIGMAR1 (0.40) | SIGMAR1SLC6A4SLC6A3CASRHTR2B | |
| SCHEMBL29198591 | 0.82 | POLB (0.54) | SIGMAR1CASRPOLB | |
| SCHEMBL178501 | 0.80 | SLC6A4 (0.39) | SIGMAR1SLC6A4SLC6A3HTR2BGPR65 | |
| SCHEMBL12463310 | 0.75 | HTR2B (0.42) | SIGMAR1SLC6A4SLC6A3HTR2BGPR65 | |
| SCHEMBL28339998 | 0.75 | CASR (0.56) | SIGMAR1SLC6A4SLC6A3CASRHTR2B | |
| SCHEMBL21091967 | 0.75 | CASR (0.56) | SIGMAR1SLC6A4SLC6A3CASRHTR2B | |
| SCHEMBL13077642 | 0.75 | CASR (0.56) | SIGMAR1SLC6A4SLC6A3CASRHTR2B | |
| SCHEMBL30488987 | 0.75 | CASR (0.56) | SIGMAR1SLC6A4SLC6A3CASRHTR2B | |
| SCHEMBL10039768 | 0.72 | CASR (0.73) | CASR | |
| SCHEMBL24017669 | 0.72 | SIGMAR1 (0.37) | SIGMAR1SLC6A4SLC6A3HTR2BGPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817299-B1 | SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LTD (IN) | 2019-06-12 | — | — | EP | disclosed |