Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20557045 | 1.00 | NR1H2 (0.47) | NR1H2JAK1JAK2MAPTNAMPT | |
| SCHEMBL69764 | 0.84 | MAPT (0.54) | MAPTKEAP1NFE2L2KDM1ASTS | |
| SCHEMBL22435955 | 0.84 | JAK1 (0.54) | NR1H2JAK1JAK2NAMPTKEAP1 | |
| SCHEMBL20556787 | 0.84 | KCNK3 (0.54) | NR1H2MAPTNAMPTKEAP1NFE2L2 | |
| SCHEMBL10449417 | 0.84 | JAK1 (0.54) | NR1H2JAK1JAK2NAMPTKEAP1 | |
| SCHEMBL10320157 | 0.84 | JAK1 (0.54) | NR1H2JAK1JAK2NAMPTKEAP1 | |
| SCHEMBL4875893 | 0.84 | JAK1 (0.54) | NR1H2JAK1JAK2NAMPTKEAP1 | |
| SCHEMBL24970468 | 0.81 | FAAH (0.57) | NR1H2JAK1JAK2MAPTNAMPT | |
| SCHEMBL20567053 | 0.81 | FAAH (0.57) | NR1H2JAK1JAK2MAPTNAMPT | |
| SCHEMBL20567052 | 0.81 | FAAH (0.57) | NR1H2JAK1JAK2MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2019-08-20 | — | — | US | disclosed |
| US-10323038-B2 | Pyrazole compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2019-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10323038-B2 | Pyrazole compounds and methods of making and using same | FAAH, FAAH2, MGLL | NR1H2 377/4885JAK1 2906/4885JAK2 3181/4885 |
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | FAAH, FAAH2, MGLL | NR1H2 377/4885JAK1 2906/4885JAK2 3181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.