Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ACP3 | P15309 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866020 | 0.68 | ALDH1A1 (0.42) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL25021 | 0.66 | ALDH1A1 (0.50) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL420650 | 0.64 | ALDH1A1 (0.55) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL1330750 | 0.64 | CYP2A6 (1.00) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL8873977 | 0.64 | CYP2A6 (1.00) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL29358486 | 0.64 | CYP2A6 (1.00) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL30932938 | 0.64 | CYP2A6 (1.00) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL7643 | 0.64 | CYP2A6 (1.00) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL29477074 | 0.64 | CYP2A6 (1.00) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL13250616 | 0.63 | HSD17B10 (0.52) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | COSTANZO MICHAEL J (US) | 2012-06-28 | — | — | US | claimed |
| US-8158792-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-17 | — | — | US | claimed |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2009-06-25 | — | — | US | claimed |
| CN-109952663-A | Organic illuminating element composition for sealing and the organic illuminating element display device as manufactured by the composition | 三星SDI株式会社 | 2019-06-28 | — | — | CN | disclosed |
| CN-108559063-A | Electroluminescent polymer containing polar substituent group condensed ring structure and preparation and application thereof | 华南协同创新研究院 | 2018-09-21 | — | — | CN | disclosed |
| US-8536189-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-09-17 | — | — | US | disclosed |
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | COSTANZO MICHAEL J (US) | 2012-06-28 | — | — | US | disclosed |
| US-8158792-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-17 | — | — | US | disclosed |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | TPSAB1, TPSB2, TPSD1 | ALDH1A1 450/4885CYP2A6 459/4885HSD17B10 1711/4885 |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | TPSAB1, TPSB2, TPSD1 | ALDH1A1 450/4885CYP2A6 459/4885HSD17B10 1711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.