Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.61 |
| ▸ | APP | P05067 | 14/20 | 0.59 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16950690 | 0.83 | TRPA1 (0.43) | TRPA1APPALDH1A1TDP1EPHX2 | |
| SCHEMBL686127 | 0.82 | TRPA1 (0.66) | TRPA1APPTRIM24ALDH1A1HPGD | |
| SCHEMBL30203126 | 0.82 | APP (0.63) | APPTRIM24ALDH1A1HPGDALDH5A1 | |
| SCHEMBL856737 | 0.82 | APP (0.63) | APPTRIM24ALDH1A1HPGDALDH5A1 | |
| SCHEMBL16957537 | 0.80 | TRPA1 (0.41) | TRPA1APPALDH1A1EPHX2 | |
| SCHEMBL16961340 | 0.79 | NOTUM (0.40) | TRPA1APPALDH1A1 | |
| SCHEMBL16953874 | 0.79 | TRPA1 (0.40) | TRPA1APPALDH1A1 | |
| SCHEMBL16951315 | 0.79 | TRPA1 (0.40) | TRPA1APPALDH1A1 | |
| SCHEMBL16951152 | 0.79 | TRPA1 (0.43) | TRPA1APPALDH1A1TDP1BCHE | |
| SCHEMBL27377995 | 0.78 | APP (0.41) | TRPA1APPALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498692-A1 | ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | Cognition Therapeutics, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |