SCHEMBL856737

SCHEMBL856737

O=Cc1ccc(O)c(OC(F)(F)F)c1

nearest known ligand 0.63

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
APP P05067 13/20 0.63
ALDH1A1 P00352 4/20 0.61
ALDH5A1 P51649 2/20 0.61
ABAT P80404 2/20 0.61
TRIM24 O15164 1/20 0.61
HPGD P15428 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
TRIM33 Q9UPN9 1/20 0.61
KDM4E B2RXH2 1/20 0.52
PTGS2 P35354 1/20 0.52
RAB9A P51151 1/20 0.52
AOX1 Q06278 1/20 0.47
TSHR P16473 1/20 0.43
XDH P47989 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30203126 1.00 APP (0.63) APPALDH1A1ALDH5A1ABATTRIM24
SCHEMBL24445666 0.86 ALDH1A1 (0.61) APPALDH1A1ALDH5A1ABATTRIM24
SCHEMBL6442449 0.85 ALDH1A1 (0.56) APPALDH1A1ALDH5A1ABATTRIM24
SCHEMBL6445440 0.85 ALDH1A1 (0.56) APPALDH1A1ALDH5A1ABATTRIM24
SCHEMBL8466367 0.82 ALDH1A1 (0.66) APPALDH1A1ALDH5A1ABATTRIM24
SCHEMBL21095690 0.82 TRPA1 (0.61) APPALDH1A1ALDH5A1ABATTRIM24
SCHEMBL11971265 0.80 APP (0.78) APPKDM4E
SCHEMBL11971260 0.80 APP (0.78) APPKDM4E
SCHEMBL3621190 0.80 ALDH1A1 (0.44) APPALDH1A1ALDH5A1ABATTRIM24
SCHEMBL22555972 0.79 APP (0.76) APPALDH1A1HPGDTDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114634429-B Photosensitive diamine monomer and preparation method thereof, resin containing photosensitive diamine monomer and photosensitive resin composition 波米科技有限公司 2022-11-22 CN claimed
CN-114634429-A Photosensitive diamine monomer, preparation method thereof, resin containing photosensitive diamine monomer and photosensitive resin composition 波米科技有限公司 2022-06-17 CN claimed
US-20260132111-A1 Host-Targeted Pan-Respiratory Antiviral Small Molecule Therapeutics PROSETTA BIOSCIENCES INC (US) 2026-05-14 US disclosed
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed
US-12466795-B2 Isoindoline compositions and methods for treating neurodegenerative disease COGNITION THERAPEUTICS, INC. (US) 2025-11-11 US disclosed
US-12459901-B2 Host-targeted pan-respiratory antiviral small molecule therapeutics PROSETTA BIOSCIENCES, INC. (US) 2025-11-04 US disclosed
US-20250188044-A1 TRIAZOLONE COMPOUND, PHARMACEUTICAL USE THEREOF AND PHARMACEUTICAL COMPOSITION HARBIN MEDISAN PHARMACEUTICAL CO., LTD. (CN) 2025-06-12 US disclosed
US-20250136555-A1 HYDANTOIN COMPOUND AND MEDICAL USE THEREOF HARBIN MEDISAN PHARMACEUTICAL CO., LTD. (CN) 2025-05-01 US disclosed
WO-2024175026-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF 哈尔滨三联药业股份有限公司 2024-08-29 WO disclosed
CN-118546109-A Nitrogen-containing heterocyclic compound and medical application thereof 哈尔滨三联药业股份有限公司 2024-08-27 CN disclosed
EP-4402124-A1 NOVEL HOST-TARGETED PAN-RESPIRATORY ANTIVIRAL SMALL MOLECULE THERAPEUTICS Prosetta Biosciences, Inc. (US) 2024-07-24 EP disclosed
US-20050192283-A1 Fused-aryl and heteroaryl derivatives and methods of their use WYETH (US) 2005-09-01 US disclosed
US-20050187251-A1 Substituted N-heterocycle derivatives and methods of their use WYETH (US) 2005-08-25 US disclosed
US-20050171115-A1 Alkanol and cycloalkanol-amine derivatives and methods of their use WYETH (US) 2005-08-04 US disclosed
US-20050148595-A1 Arylalkyl-and cycloalkylalkyl-piperazine derivatives and methods of their use WYETH (US) 2005-07-07 US disclosed
US-20050143579-A1 Substituted aryl cycloalkanol derivatives and methods of their use WYETH (US) 2005-06-30 US disclosed
WO-2005037207-A2 ARYLALKYL-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF CONDITIONS AMELIORATED BY MONOAMINE REUPTAKE INCLUDING VASOMOTOR SYMPTOMS (VMS) WYETH (US) 2005-04-28 WO disclosed
WO-2005037809-A1 SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2005-04-28 WO disclosed
WO-2005037283-A1 FUSED-ARYL AND HETEROARYL DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2005-04-28 WO disclosed
WO-2005037279-A1 1- 2’ (1, 4’-BIPERIDIN-1’-YL)-1- (PHENYL) -ETHYL CYCLOHEXANOL DERIVATIVES AS MONOAMINE REUPTAKE MODULATORS FOR THE TREATMENT OF VISOMOTOR SYMPTOMS WYETH (US) 2005-04-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 APP 671/4885ALDH1A1 1334/4885ALDH5A1 3137/4885
US-20050143579-A1 Substituted aryl cycloalkanol derivatives and methods of their use HTR3A, MAOA, FAAH APP 3167/4885ALDH1A1 445/4885ALDH5A1 236/4885
US-20260132111-A1 Host-Targeted Pan-Respiratory Antiviral Small Molecule Therapeutics NCOR1, HAVCR2, NR3C1 APP 4227/4885ALDH1A1 3991/4885ALDH5A1 4806/4885
US-20050148595-A1 Arylalkyl-and cycloalkylalkyl-piperazine derivatives and methods of their use GLS, HTR5A, HTR3A APP 4000/4885ALDH1A1 244/4885ALDH5A1 187/4885
US-20250188044-A1 TRIAZOLONE COMPOUND, PHARMACEUTICAL USE THEREOF AND PHARMACEUTICAL COMPOSITION PPARD, PPARA, PPARG APP 892/4885ALDH1A1 879/4885ALDH5A1 360/4885
US-12466795-B2 Isoindoline compositions and methods for treating neurodegenerative disease TMEM97, SLC18A2, PSD APP 37/4885ALDH1A1 4160/4885ALDH5A1 3758/4885
US-20050171115-A1 Alkanol and cycloalkanol-amine derivatives and methods of their use FAAH, HTR3A, MAOA APP 1903/4885ALDH1A1 439/4885ALDH5A1 255/4885
US-20050187251-A1 Substituted N-heterocycle derivatives and methods of their use MAOA, MAOB, SDHA APP 3444/4885ALDH1A1 559/4885ALDH5A1 117/4885
US-12459901-B2 Host-targeted pan-respiratory antiviral small molecule therapeutics MAVS, SARS1, ZC3HAV1 APP 2808/4885ALDH1A1 4359/4885ALDH5A1 4404/4885
US-20250136555-A1 HYDANTOIN COMPOUND AND MEDICAL USE THEREOF PPARD, PPARA, PPARG APP 1480/4885ALDH1A1 807/4885ALDH5A1 690/4885
US-20050192283-A1 Fused-aryl and heteroaryl derivatives and methods of their use COMT, MAOA, HTR3A APP 4317/4885ALDH1A1 434/4885ALDH5A1 130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.