Dramedilol

Dramedilol

SCHEMBL2109623

COc1ccc(CCNCC(O)COc2ccc(NN=C(C)C)nn2)cc1OC

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.55
ADRB2 P07550 2/20 0.54
ADRB1 P08588 2/20 0.54
HTR1A P08908 1/20 0.54
ADRA2C P18825 1/20 0.54
SLC6A4 P31645 1/20 0.54
ADRA1A P35348 1/20 0.54
HTR2B P41595 1/20 0.54
SLC6A3 Q01959 1/20 0.54
KCNH2 Q12809 1/20 0.54
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.52
ATM Q13315 1/20 0.51
ADRB3 P13945 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dramedilol SCHEMBL9700551 0.99 KMT2A (0.56) KMT2AADRB2ADRB1HTR1AADRA2C
Dramedilol SCHEMBL9699524 0.99 KMT2A (0.56) KMT2AADRB2ADRB1HTR1AADRA2C
Hydrochloric Acid SCHEMBL9700517 0.87 KMT2A (0.61) KMT2AADRB2ADRB1HTR1AADRA2C
Hydrochloric Acid SCHEMBL9700595 0.86 KMT2A (0.54) KMT2AADRB2ADRB1HTR1AADRA2C
Hydrochloric Acid SCHEMBL9700593 0.86 KMT2A (0.54) KMT2AADRB2ADRB1HTR1AADRA2C
Hydrochloric Acid SCHEMBL9700715 0.84 ADRB2 (0.51) KMT2AADRB2ADRB1HTR1AADRA2C
Hydrochloric Acid SCHEMBL9700719 0.84 ADRB2 (0.51) KMT2AADRB2ADRB1HTR1AADRA2C
Hydrochloric Acid SCHEMBL11229646 0.84 ADRB1 (0.47) KMT2AADRB2ADRB1MEN1ADRB3
SCHEMBL9700545 0.80 ADRB2 (0.53) KMT2AADRB2ADRB1HTR1AADRA2C
SCHEMBL9700562 0.80 ADRB2 (0.53) KMT2AADRB2ADRB1HTR1AADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-0274409-A2 Process for preparing alkoxyalkyl-idenehydrazinopyridazine derivatives I.S.F. Socièta per Azioni (IT) 1988-07-13 EP claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
EP-2717860-A1 CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION STI Pharma, LLC (US) 2014-04-16 EP disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
US-5082939-A Pyridazine derivatives I.S.F. SOCIETA PER AZIONI (IT) 1992-01-21 US disclosed
US-5082939-A Pyridazine derivatives I.S.F. SOCIETA PER AZIONI (IT) 1992-01-21 US disclosed
US-4873328-A Process for preparing alkoxyalkylidenehydrazinopyridazine derivatives I.S.F. SOCIETA PER AZIONI (IT) 1989-10-10 US disclosed
US-4873328-A Process for preparing alkoxyalkylidenehydrazinopyridazine derivatives I.S.F. SOCIETA PER AZIONI (IT) 1989-10-10 US disclosed
EP-0274409-A2 Process for preparing alkoxyalkyl-idenehydrazinopyridazine derivatives I.S.F. Socièta per Azioni (IT) 1988-07-13 EP disclosed