Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MPO | P05164 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | KDM5A | P29375 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | OGG1 | O15527 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17124383 | 0.83 | MPO (0.61) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL2678949 | 0.82 | MPO (0.80) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL343630 | 0.82 | MPO (0.80) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL9696902 | 0.80 | MAPT (0.57) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL28188923 | 0.79 | MPO (0.76) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL2830827 | 0.79 | PLK1 (0.68) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL27597341 | 0.79 | PLK1 (0.68) | CA2PLK1HDAC6 | |
| SCHEMBL2107844 | 0.79 | OGG1 (0.61) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| Hydrochloric Acid SCHEMBL2108580 | 0.78 | OGG1 (0.59) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL18454411 | 0.76 | MPO (0.53) | ALDH1A1KDM4EMAPTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111995620-A | Preparation method of 1,3, 4-thiadiazole compound and compound prepared by same | 重庆医科大学 | 2020-11-27 | — | — | CN | disclosed |
| US-20130345220-A1 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2013-12-26 | — | — | US | disclosed |
| US-8569345-B2 | Compounds and compositions as LXR modulators | MOLTENI VALENTINA (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120214812-A1 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2012-08-23 | — | — | US | disclosed |
| US-8158662-B2 | Compounds and compositions as LXR modulators | HAMILTON (BM) | 2012-04-17 | — | — | US | disclosed |
| US-20090325981-A1 | Compounds and compositions as lxr modulators | IRM LLC (BM) | 2009-12-31 | — | — | US | disclosed |
| EP-1713799-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM, LLC (BM) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005092304-A2 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005077124-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | disclosed |
| US-4985461-A | Insecticidal N'-substituted-N,N'-diacylhydrazines | ROHM AND HAAS COMPANY (US) | 1991-01-15 | — | — | US | disclosed |
| US-4897485-A | Insecticidal pyrid-3-yl-2,3-diaza-butadien-1-yl-disulfies | CIBA-GEIGY CORPORATION (US) | 1990-01-30 | — | — | US | disclosed |
| US-4699913-A | Substituted 4,5-dihydro-1,3,4-thiadiazoles useful as insecticides | CIBA-GEIGY CORPORATION (US) | 1987-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345220-A1 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | NR1H2, NR1H3, NR1H4 | ALDH1A1 3768/4885KDM4E 2982/4885MAPT 3347/4885 |
| US-20090325981-A1 | Compounds and compositions as lxr modulators | NR1H2, NR1H3, NR1H4 | ALDH1A1 3768/4885KDM4E 2982/4885MAPT 3347/4885 |
| US-20120214812-A1 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | NR1H2, NR1H3, NR1H4 | ALDH1A1 3768/4885KDM4E 2982/4885MAPT 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.