Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | OGG1 | O15527 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2109646 | 0.80 | ALDH1A1 (0.61) | MAPTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL9695086 | 0.80 | PARP10 (0.43) | MAPTALDH1A1L3MBTL1CYP3A4BLM | |
| SCHEMBL17124383 | 0.79 | MPO (0.61) | MAPTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL343630 | 0.78 | MPO (0.80) | MAPTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2678949 | 0.78 | MPO (0.80) | MAPTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL9696756 | 0.78 | TSHR (0.52) | MAPTKDM4EALDH1A1L3MBTL1HIF1A | |
| SCHEMBL9696719 | 0.78 | ALDH1A1 (0.41) | MAPTALDH1A1LMNAL3MBTL1CA1 | |
| SCHEMBL28188923 | 0.76 | MPO (0.76) | MAPTKDM4EALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8179270 | 0.76 | CA1 (0.43) | MAPTALDH1A1LMNAL3MBTL1CA1 | |
| SCHEMBL2830827 | 0.76 | PLK1 (0.68) | MAPTKDM4EALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116833-A | ANTIBIOTIC C-3 DITHIOACETAL-SUBSTITUTED CARBAPENEM COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0481511-A2 | Antibiotic C-3 dithioacetal-substituted carbapenem compounds, compositions, and use thereof | Bristol-Myers Squibb Company (US) | 1992-04-22 | — | — | EP | disclosed |