Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12516420 | 1.00 | SLC6A2 (0.62) | SLC6A2PDE4DBCHEPRKAG1PRKAA2 | |
| SCHEMBL2220309 | 1.00 | SLC6A2 (0.62) | SLC6A2PDE4DBCHEPRKAG1PRKAA2 | |
| SCHEMBL13793171 | 0.95 | SLC6A2 (0.68) | SLC6A2PDE4DBCHEADORA2A | |
| SCHEMBL3917713 | 0.95 | SLC6A2 (0.68) | SLC6A2PDE4DBCHEADORA2A | |
| SCHEMBL12803755 | 0.92 | SLC6A2 (0.55) | SLC6A2PDE4DPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL19145004 | 0.90 | SLC6A2 (0.69) | SLC6A2PDE4DBCHETSHRCYP2C19 | |
| SCHEMBL12803420 | 0.85 | SLC6A2 (0.48) | SLC6A2PDE4DPRKAG1PRKAA2PRKAB1 | |
| SCHEMBL2223610 | 0.85 | SLC6A2 (0.48) | SLC6A2PDE4DADORA2A | |
| SCHEMBL24894599 | 0.84 | SLC6A2 (0.58) | SLC6A2PDE4DBCHETSHRCYP2C19 | |
| SCHEMBL22710225 | 0.84 | SLC6A2 (0.58) | SLC6A2PDE4DBCHETSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10478425-B2 | 5-phenylazaindole derivative having AMPK-activating activity | SHIONOGI & CO., LTD. (JP) | 2019-11-19 | — | — | US | disclosed |
| US-10406140-B2 | 5-substituted benzimidazole and 5-substituted azabenzimidazole derivative both having AMPK activation effect | SHIONOGI & CO., LTD. (JP) | 2019-09-10 | — | — | US | disclosed |
| US-20190183866-A1 | 5-SUBSTITUTED BENZIMIDAZOLE AND 5-SUBSTITUTED AZABENZIMIDAZOLE DERIVATIVE BOTH HAVING AMPK ACTIVATION EFFECT | SHIONOGI & CO., LTD. (JP) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190183866-A1 | 5-SUBSTITUTED BENZIMIDAZOLE AND 5-SUBSTITUTED AZABENZIMIDAZOLE DERIVATIVE BOTH HAVING AMPK ACTIVATION EFFECT | PRKAG2, PRKAB2, PRKAG1 | SLC6A2 4656/4885PDE4D 201/4885BCHE 3233/4885 |
| US-10406140-B2 | 5-substituted benzimidazole and 5-substituted azabenzimidazole derivative both having AMPK activation effect | PRKAG2, PRKAB2, PRKAG1 | SLC6A2 4656/4885PDE4D 201/4885BCHE 3233/4885 |
| US-10478425-B2 | 5-phenylazaindole derivative having AMPK-activating activity | PRKAG2, PRKAG1, PRKAB2 | SLC6A2 4754/4885PDE4D 315/4885BCHE 2714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.