Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26073815 | 1.00 | MEN1 (0.55) | MEN1KMT2ASMN1; SMN2TSHRPOLB | |
| SCHEMBL26073805 | 0.91 | KMT2A (0.62) | MEN1KMT2ASMN1; SMN2TSHRPOLB | |
| SCHEMBL25837407 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2JAK3TEAD1 | |
| SCHEMBL26502211 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2JAK3TEAD1 | |
| SCHEMBL26073809 | 0.81 | KMT2A (0.47) | MEN1KMT2ASMN1; SMN2JAK3KDM4E | |
| SCHEMBL25514716 | 0.80 | KMT2A (0.59) | MEN1KMT2ASMN1; SMN2TSHRPOLB | |
| SCHEMBL26077171 | 0.79 | KDM5A (0.46) | KMT2AJAK3KDM4ELMNATEAD1 | |
| SCHEMBL21097015 | 0.79 | LMNA (0.46) | KMT2ASMN1; SMN2POLBJAK3LMNA | |
| SCHEMBL19229767 | 0.76 | TEAD1 (0.47) | JAK3TEAD1 | |
| SCHEMBL9921877 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRPOLBGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185518-A9 | WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1 | AILERON THERAPEUTICS, INC. | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185518-A9 | WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1 | BCL2L11, BCL2L1, BCL2L13 | MEN1 1644/4885KMT2A 3692/4885SMN1; SMN2 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.