Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 6/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 2/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21097019 | 0.91 | DUSP22 (0.40) | LMNAPOLBKMT2AACKR3JAK3 | |
| SCHEMBL21097023 | 0.91 | DUSP22 (0.40) | LMNAPOLBKMT2AACKR3JAK3 | |
| SCHEMBL21097026 | 0.91 | KMT2A (0.51) | LMNAPOLBKMT2ASMN1; SMN2ACKR3 | |
| SCHEMBL25837407 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2JAK3TEAD1BTKTEAD3 | |
| SCHEMBL26502211 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2JAK3TEAD1BTKTEAD3 | |
| SCHEMBL2146353 | 0.81 | LMNA (0.56) | LMNAPOLBKMT2ASMN1; SMN2ACKR3 | |
| SCHEMBL26077171 | 0.79 | KDM5A (0.46) | LMNAKMT2AJAK3TEAD1TEAD3 | |
| SCHEMBL21097014 | 0.79 | MEN1 (0.55) | LMNAPOLBKMT2ASMN1; SMN2JAK3 | |
| SCHEMBL26073815 | 0.79 | MEN1 (0.55) | LMNAPOLBKMT2ASMN1; SMN2JAK3 | |
| SCHEMBL21097025 | 0.78 | ITGB3 (0.34) | KMT2AACKR3JAK3BTKPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185518-A9 | WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1 | AILERON THERAPEUTICS, INC. | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185518-A9 | WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1 | BCL2L11, BCL2L1, BCL2L13 | LMNA 3482/4885POLB 1736/4885KMT2A 3692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.