Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253858 | 0.91 | ADORA3 (0.81) | ADORA3TSHRCYP3A4NFKB1BLM | |
| SCHEMBL9388463 | 0.91 | ADORA3 (0.81) | ADORA3TSHRCYP3A4NFKB1BLM | |
| SCHEMBL13975993 | 0.88 | TSHR (0.85) | ADORA3TSHRCYP3A4NFKB1BLM | |
| SCHEMBL21139455 | 0.88 | TSHR (0.85) | ADORA3TSHRCYP3A4NFKB1BLM | |
| SCHEMBL17371120 | 0.88 | TSHR (0.85) | ADORA3TSHRCYP3A4NFKB1BLM | |
| SCHEMBL4542860 | 0.88 | TSHR (0.85) | ADORA3TSHRCYP3A4NFKB1BLM | |
| SCHEMBL20626300 | 0.84 | SLC29A1 (0.84) | ADORA3ADORA2ATP53SLC29A1TDP1 | |
| SCHEMBL63259 | 0.84 | SLC29A1 (0.84) | ADORA3ADORA2ATP53SLC29A1TDP1 | |
| SCHEMBL17824431 | 0.84 | SLC29A1 (0.84) | ADORA3ADORA2ATP53SLC29A1TDP1 | |
| SCHEMBL75915 | 0.84 | SLC29A1 (0.84) | ADORA3ADORA2ATP53SLC29A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10342818-B2 | Dual-action compounds targeting adenosine A2A receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases | ACADEMIA SINICA (TW) | 2019-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10342818-B2 | Dual-action compounds targeting adenosine A2A receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases | ADORA2A, ADORA1, ADORA3 | ADORA3 3/4885TSHR 484/4885CYP3A4 4325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.