Flutomidate

Flutomidate

SCHEMBL2109834

CCOC(=O)c1cncn1C(C)c1ccc(F)cc1

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 7/20 0.77
GABRB2 P47870 7/20 0.77
CYP1A2 P05177 2/20 0.77
CYP3A4 P08684 2/20 0.77
CYP11B1 P15538 2/20 0.77
CYP11B2 P19099 2/20 0.77
LMNA P02545 2/20 0.77
GABRA2 P47869 2/20 0.77
CYP2C9 P11712 1/20 0.77
CYP2C19 P33261 1/20 0.77
ABCB11 O95342 1/20 0.77
MAPK1 P28482 1/20 0.55
GPBAR1 Q8TDU6 3/20 0.54
ALDH1A1 P00352 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
NOD2 Q9HC29 1/20 0.41
NOD1 Q9Y239 1/20 0.41
TGFBR1 P36897 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flutomidate SCHEMBL20866543 1.00 GABRA1 (0.77) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
SCHEMBL29100478 0.89 GABRA1 (0.79) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
S-Etomidate SCHEMBL39486 0.87 GABRA1 (1.00) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
Etomidate SCHEMBL39487 0.87 GABRA1 (1.00) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
Amidate SCHEMBL39485 0.87 GABRA1 (1.00) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
Amidate SCHEMBL1817757 0.87 GABRA1 (1.00) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
SCHEMBL20866483 0.86 GABRA1 (0.76) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
SCHEMBL20866542 0.86 GABRA1 (0.76) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
Amidate SCHEMBL22502728 0.86 GABRA1 (0.97) GABRA1GABRB2CYP1A2CYP3A4CYP11B1
Etomidate SCHEMBL11323863 0.86 GABRA1 (0.97) GABRA1GABRB2CYP1A2CYP3A4CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-20200277264-A1 Compounds for Treating Disorders Associated with Abnormal Steroidogenesis THE GENERAL HOSPITAL CORPORATION 2020-09-03 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
WO-2019067021-A1 COMPOUNDS FOR TREATING DISORDERS ASSOCIATED WITH ABNORMAL STEROIDOGENESIS THE GENERAL HOSPITAL CORPORATION (US) 2019-04-04 WO disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
US-7905852-B2 Skin-contacting-adhesive free dressing JENNINGS-SPRING BARBARA 2011-03-15 US disclosed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US disclosed
WO-2010024870-A1 SKIN-CONTACTING-ADHESIVE FREE DRESSING JENNINGS-SPRING BARBARA BROOKE (US) 2010-03-04 WO disclosed
US-20090005722-A1 Skin-contacting-adhesive free dressing JENNLNGS-SPRING BARBARA 2009-01-01 US disclosed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP disclosed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO disclosed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200277264-A1 Compounds for Treating Disorders Associated with Abnormal Steroidogenesis CYP27A1, HSD17B11, NR5A1 GABRA1 1222/4885GABRB2 390/4885CYP1A2 343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.