Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Amidate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 1.00 |
| ▸ | GABRB2 known ✓ | P47870 | 6/20 | 1.00 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 1.00 |
| ▸ | CYP11B2 | P19099 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| S-Etomidate SCHEMBL39486 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL1817757 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Etomidate SCHEMBL39487 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL901536 | 0.99 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL21773562 | 0.99 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL363786 | 0.99 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL1098161 | 0.99 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL22502728 | 0.99 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL668471 | 0.99 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL11235297 | 0.99 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 19187 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122084580-A | Preparation method of nano-plasma super-surface biosensor and application of nano-plasma super-surface biosensor in detection of novel psychoactive substances | — | 2026-05-26 | — | — | CN | claimed |
| CN-122072263-A | Analysis method of related substances of moetime hydrochloride injection | 锦州奥鸿药业有限责任公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122037215-A | Molecular imprinting hydrogen bond organic framework adsorption material and preparation method and application thereof | 重庆市食品药品检验检测研究院 | 2026-05-15 | — | — | CN | claimed |
| CN-122016983-A | Method for detecting multiple drugs in hair | 公安部鉴定中心 | 2026-05-12 | — | — | CN | claimed |
| EP-4719552-A1 | INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2026-04-08 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| CN-117310015-B | Method for measuring etomidate content in electronic tobacco tar | 广州金域司法鉴定技术有限公司 | 2026-02-27 | — | — | CN | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| US-20250345276-A1 | O/W-EMULSIONS COMPRISING SEMIFLUORINATED ALKANES | NOVALIQ GMBH (DE) | 2025-11-13 | — | — | US | claimed |
| CN-86106046-A | The acid amides of teicoplanin compounds | — | 1987-08-12 | — | — | CN | claimed |
| EP-0197571-A2 | Novel derivatives of gamma-cyclodextrin | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-15 | — | — | EP | claimed |
| US-4597878-A | Polyphenolic acid adducts | VENTURE INNOVATIONS, INC. (US) | 1986-07-01 | — | — | US | claimed |
| US-4529803-A | Reacting imidazole with an unsaturated carboxylic ester | THE DOW CHEMICAL COMPANY (US) | 1985-07-16 | — | — | US | claimed |
| WO-1985002767-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING DRUGS WHICH ARE INSTABLE OR SPARINGLY SOLUBLE IN WATER AND METHODS FOR THEIR PREPARATION | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-07-04 | — | — | WO | claimed |
| EP-0134085-A1 | DNA encoding a GRF precursor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1985-03-13 | — | — | EP | claimed |
| EP-0049484-B1 | A PROCESS FOR THE PRODUCTION OF A FLUID LOSS REDUCING ADDITIVE FOR AN OIL-BASED WELL WORKING FLUID | B W MUD LIMITED (GB) | 1984-12-19 | — | — | EP | claimed |
| EP-0049484-A1 | A process for the production of a fluid loss reducing additive for an oil-based well working fluid | B W MUD LIMITED (GB) | 1982-04-14 | — | — | EP | claimed |
| US-4289783-A | Etomidate-containing compositions | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-09-15 | — | — | US | claimed |
| US-3991072-A | Racemization of lower alkyl imidazole carboxylates | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-09 | — | — | US | claimed |