Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13897310 | 0.88 | L3MBTL1 (0.43) | L3MBTL1GAAALOX12MAPTALDH1A1 | |
| SCHEMBL18037724 | 0.84 | FURIN (0.44) | L3MBTL1GAAALOX12MAPTALDH1A1 | |
| SCHEMBL22815479 | 0.82 | MAOB (0.46) | SMN1; SMN2 | |
| SCHEMBL20197999 | 0.82 | MAPT (0.43) | L3MBTL1ALOX12MAPTALDH1A1KMT2A | |
| SCHEMBL15176976 | 0.81 | L3MBTL1 (0.48) | L3MBTL1GAAALOX12MAPTALDH1A1 | |
| SCHEMBL22749389 | 0.80 | KMT2A (0.49) | L3MBTL1ALOX12MAPTALDH1A1HPGD | |
| SCHEMBL557680 | 0.78 | GPR119 (0.41) | L3MBTL1GAAALOX12MAPTKMT2A | |
| SCHEMBL1744893 | 0.78 | GPR119 (0.41) | L3MBTL1GAAALOX12MAPTKMT2A | |
| SCHEMBL14616553 | 0.78 | MAPT (0.44) | GAAMAPTALDH1A1HPGDKMT2A | |
| SCHEMBL13939362 | 0.77 | MAPT (0.41) | L3MBTL1GAAALOX12MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011458-A1 | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITOR-CONJUGATES AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-01-20 | — | — | WO | disclosed |
| WO-2019109188-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-06-13 | — | — | WO | disclosed |