Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | MERTK | Q12866 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 11/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790192 | 0.83 | KEAP1 (0.62) | KEAP1MERTKNAMPTAXLFLT3 | |
| SCHEMBL24484881 | 0.81 | KEAP1 (0.64) | KEAP1MERTKAXLFLT3DYRK1A | |
| SCHEMBL74518 | 0.81 | KEAP1 (0.68) | KEAP1MERTKNAMPTAXLFLT3 | |
| SCHEMBL17788633 | 0.81 | KEAP1 (0.58) | KEAP1MERTKNAMPTDYRK1APAK1 | |
| SCHEMBL24529535 | 0.80 | DYRK1A (0.47) | KEAP1MERTKAXLFLT3DYRK1A | |
| Ammonia Solution, Strong SCHEMBL28922912 | 0.80 | KEAP1 (0.66) | KEAP1MERTKNAMPTAXLFLT3 | |
| SCHEMBL19764528 | 0.79 | KEAP1 (0.57) | KEAP1MERTKNAMPTDYRK1APAK1 | |
| SCHEMBL23127994 | 0.78 | KEAP1 (0.55) | KEAP1NAMPTDYRK1APAK1RET | |
| SCHEMBL24529202 | 0.78 | TRIM33 (0.46) | KEAP1MERTKNAMPTAXLFLT3 | |
| SCHEMBL17196187 | 0.76 | KEAP1 (0.57) | KEAP1MERTKNAMPTDYRK1APAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10323018-B2 | Quinazoline and quinoline compounds and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10323018-B2 | Quinazoline and quinoline compounds and uses thereof | NAMPT, NQO2, NNMT | KEAP1 129/4885MERTK 1208/4885NAMPT 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.