Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM33 | Q9UPN9 | 4/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529150 | 0.84 | HTR7 (0.45) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL3920300 | 0.81 | CASR (0.59) | TRIM33AXLFLT3MERTKRET | |
| SCHEMBL24529200 | 0.78 | TRIM33 (0.41) | TRIM33AXLFLT3MERTKNAMPT | |
| SCHEMBL24529535 | 0.78 | DYRK1A (0.47) | AXLFLT3MERTKDYRK1AKEAP1 | |
| SCHEMBL21099155 | 0.78 | KEAP1 (0.58) | AXLFLT3MERTKNAMPTDYRK1A | |
| SCHEMBL3920376 | 0.76 | TRIM33 (0.44) | TRIM33AXLFLT3MERTKNAMPT | |
| SCHEMBL24529175 | 0.75 | TRIM33 (0.39) | TRIM33AXLFLT3MERTKDYRK1A | |
| SCHEMBL27181397 | 0.75 | TRIM33 (0.39) | TRIM33AXLFLT3MERTKDYRK1A | |
| SCHEMBL31380975 | 0.73 | ALDH1A3 (0.56) | TRIM33AXLFLT3MERTKNAMPT | |
| SCHEMBL24529319 | 0.71 | SYK (0.40) | HTR1AHTR1DHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |