Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099556 | 0.85 | IRAK4 (0.56) | IRAK4PTK2BRD4JAK2ALK | |
| SCHEMBL21100193 | 0.78 | IRAK4 (0.59) | IRAK4BRD4JAK2LRRK2ALK | |
| SCHEMBL21099879 | 0.74 | ULK1 (0.45) | IRAK4PTK2BRD4JAK2LRRK2 | |
| SCHEMBL21099501 | 0.74 | ALK (0.52) | PTK2ALKEGFR | |
| SCHEMBL21099812 | 0.74 | CCND3 (0.54) | IRAK4PTK2BRD4JAK2LRRK2 | |
| SCHEMBL21100190 | 0.73 | LRRK2 (0.41) | IRAK4PTK2LRRK2ALKEGFR | |
| SCHEMBL21099819 | 0.72 | IRAK4 (0.53) | IRAK4PTK2BRD4JAK2LRRK2 | |
| SCHEMBL21099658 | 0.72 | ALK (0.60) | IRAK4PTK2JAK2LRRK2ALK | |
| SCHEMBL19867381 | 0.70 | PTK2 (0.56) | IRAK4PTK2BRD4JAK2LRRK2 | |
| SCHEMBL21099572 | 0.70 | IRAK4 (0.56) | IRAK4PTK2BRD4JAK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |