Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23023801 | 0.86 | POLB (0.43) | POLBIDH1SMN1; SMN2KCNA5KCNE1 | |
| SCHEMBL1991270 | 0.84 | POLB (0.51) | POLBIDH1SMN1; SMN2KCNA5KCNE1 | |
| SCHEMBL19368165 | 0.82 | CHRM2 (0.47) | POLBIDH1SMN1; SMN2KCNA5KCNE1 | |
| SCHEMBL16461215 | 0.76 | DPP4 (0.56) | POLBIDH1SMN1; SMN2KCNA5KCNE1 | |
| SCHEMBL21783607 | 0.76 | IDH1 (0.52) | POLBIDH1SMN1; SMN2KCNA5KCNE1 | |
| SCHEMBL9963444 | 0.69 | KCNA5 (0.50) | IDH1KCNA5KCNE1ALDH1A1KCNH2 | |
| SCHEMBL16464338 | 0.68 | L3MBTL1 (0.49) | POLBIDH1SMN1; SMN2KCNA5KCNE1 | |
| SCHEMBL11989937 | 0.68 | OPRM1 (0.58) | SMN1; SMN2KCNA5LMNAALDH1A1DPP4 | |
| SCHEMBL17846504 | 0.68 | L3MBTL1 (0.53) | SMN1; SMN2L3MBTL1HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL1514881 | 0.68 | SLC6A4 (0.55) | KCNA5KCNE1ALDH1A1KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118313-A1 | IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME CORP. (US) | 2019-06-20 | — | — | WO | disclosed |