Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | LIPE | Q05469 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16669692 | 0.75 | RAB9A (0.57) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL20998533 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL306371 | 0.74 | CYP2C9 (0.56) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL29494845 | 0.68 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL240269 | 0.68 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL2309706 | 0.68 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL623961 | 0.67 | MAP4K4 (0.57) | SMN1; SMN2PLAUMEN1NPC1RAB9A | |
| SCHEMBL7172986 | 0.67 | SMN1; SMN2 (0.96) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL5991139 | 0.66 | PLAU (0.54) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL10499451 | 0.66 | MAPK1 (0.71) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2019-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | BTK, SYK, LCK | SMN1; SMN2 4791/4885LMNA 4662/4885CYP2C9 1978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.