Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | SORD | Q00796 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6066639 | 0.88 | CHEK1 (0.52) | GPR119SORDROCK2ROCK1CDC42BPB | |
| SCHEMBL13744594 | 0.85 | GPR119 (0.50) | GPR119SORDCYP2D6DPP4KCNH2 | |
| SCHEMBL25687828 | 0.82 | GPR119 (0.48) | GPR119SORDCYP2D6DPP4KCNH2 | |
| SCHEMBL16597339 | 0.81 | SORD (0.56) | GPR119SORDLSSRIPK1JAK2 | |
| SCHEMBL12424487 | 0.81 | GPR119 (0.49) | GPR119SORDCHEK1CHEK2LSS | |
| SCHEMBL4771414 | 0.81 | SORD (0.49) | GPR119SORDCYP2D6DPP4KCNH2 | |
| SCHEMBL13745108 | 0.80 | GPR119 (0.52) | GPR119SORDCYP2D6DPP4KCNH2 | |
| SCHEMBL4429602 | 0.80 | DRD2 (0.51) | GPR119PTPN11DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL2948979 | 0.79 | GPR119 (0.51) | GPR119SORDCYP2D6DPP4KCNH2 | |
| SCHEMBL1381114 | 0.79 | HRH3 (0.58) | GPR119SORDROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688568-B1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-06-19 | — | — | EP | disclosed |