Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15077045 | 0.79 | HTT (0.51) | LMNAALDH1A1HTTGAASMN1; SMN2 | |
| SCHEMBL16306950 | 0.79 | VCAM1 (0.43) | LMNARECQLALDH1A1HTTMAPT | |
| SCHEMBL19255842 | 0.79 | LMNA (0.57) | LMNAALDH1A1HTTMAPTNPSR1 | |
| SCHEMBL15077326 | 0.78 | HTT (0.50) | LMNAALDH1A1HTTMAPTGAA | |
| SCHEMBL22368467 | 0.78 | HTT (0.50) | LMNAALDH1A1HTTMAPTGAA | |
| SCHEMBL17417188 | 0.78 | HTT (0.54) | LMNAALDH1A1HTTMAPTGAA | |
| SCHEMBL16022237 | 0.77 | ALDH1A1 (0.42) | LMNAALDH1A1HTTMAPTGAA | |
| SCHEMBL16807785 | 0.76 | HTT (0.49) | LMNAALDH1A1HTTMAPTGAA | |
| SCHEMBL24321567 | 0.75 | HTT (0.48) | LMNAALDH1A1HTTMAPTGAA | |
| SCHEMBL21102036 | 0.75 | LMNA (0.61) | LMNAALDH1A1HTTGAAVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |