Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343224 | 0.86 | ALDH1A1 (0.74) | ALDH1A1MAPTPOLBHTTGAA | |
| SCHEMBL21102719 | 0.86 | POLB (0.63) | ALDH1A1MAPTPOLBHTTCA12 | |
| SCHEMBL21101766 | 0.85 | BRD4 (0.55) | ALDH1A1MAPTATMPOLBMEN1 | |
| SCHEMBL30098959 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTATMPOLBMEN1 | |
| SCHEMBL13752250 | 0.78 | HDAC3 (0.64) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL21102206 | 0.78 | ALDH1A1 (0.51) | ALDH1A1MAPTPOLBMEN1KMT2A | |
| SCHEMBL26188045 | 0.77 | ALDH1A1 (0.57) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL23591991 | 0.77 | TGM2 (0.60) | ALDH1A1MAPTMAPK14POLBRECQL | |
| SCHEMBL12971593 | 0.77 | POLB (0.58) | ALDH1A1MAPTATMPOLBMEN1 | |
| SCHEMBL21902832 | 0.76 | NPC1 (0.52) | ALDH1A1MAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |