Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101762 | 0.85 | ALDH1A1 (0.55) | LMNAPOLBATMALDH1A1SMN1; SMN2 | |
| SCHEMBL21102719 | 0.84 | POLB (0.63) | POLBALDH1A1CTSDMAPTPKM | |
| SCHEMBL21102116 | 0.82 | BRD4 (0.49) | BRD4LMNAPOLBMGAT2SMN1; SMN2 | |
| SCHEMBL21101772 | 0.81 | BRD4 (0.49) | BRD4LMNAPOLBALDH1A1MGAT2 | |
| SCHEMBL21101777 | 0.81 | LMNA (0.53) | BRD4LMNAPOLBALDH1A1NPSR1 | |
| SCHEMBL23591990 | 0.78 | LMNA (0.54) | BRD4LMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL1101999 | 0.76 | ATM (0.72) | POLBATMALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13752250 | 0.76 | HDAC3 (0.64) | BRD4LMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL12971593 | 0.74 | POLB (0.58) | POLBATMALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL21902832 | 0.73 | NPC1 (0.52) | LMNAPOLBALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |