SCHEMBL21111342

SCHEMBL21111342

O=S(=O)(O)c1ccc(CCCCc2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.58
TSHR P16473 1/20 0.58
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
CA2 P00918 2/20 0.50
MAOB P27338 2/20 0.50
MAPT P10636 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50
POLB P06746 1/20 0.50
CYP2D6 P10635 1/20 0.50
HDAC1 Q13547 4/20 0.49
ALDH1A1 P00352 1/20 0.49
HDAC3 O15379 2/20 0.48
HDAC4 P56524 2/20 0.48
HDAC7 Q8WUI4 2/20 0.48
HDAC2 Q92769 2/20 0.48
HDAC10 Q969S8 2/20 0.48
HDAC11 Q96DB2 2/20 0.48
HDAC8 Q9BY41 2/20 0.48
HDAC6 Q9UBN7 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28276274 0.96 SMN1; SMN2 (0.58) SMN1; SMN2TSHRMEN1KMT2ACA2
SCHEMBL6929012 0.92 TSHR (0.62) SMN1; SMN2TSHRCA2MAOBMAPT
SCHEMBL30446884 0.92 CA2 (0.57) SMN1; SMN2TSHRCA2POLBCYP2D6
SCHEMBL1806457 0.84 CA2 (0.50) SMN1; SMN2TSHRCA2CYP2D6ALDH1A1
SCHEMBL1806460 0.84 CA2 (0.70) SMN1; SMN2TSHRCA2ALDH1A1
SCHEMBL9640255 0.84 TSHR (0.53) SMN1; SMN2TSHRMEN1KMT2ACA2
SCHEMBL7457090 0.84 MMP12 (0.44) SMN1; SMN2TSHRHDAC1HDAC3HDAC4
SCHEMBL3151100 0.83 TSHR (0.62) SMN1; SMN2TSHRCA2POLBCYP2D6
SCHEMBL9277016 0.83 SIGMAR1 (0.47) SMN1; SMN2TSHRPOLBCYP2D6SIGMAR1
SCHEMBL9773401 0.83 FFAR1 (0.56) SMN1; SMN2TSHRCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3501546-A2 CYSTEINE DRUG CONJUGATES AND USE OF SAME Seattle Genetics, Inc. (US) 2019-06-26 EP disclosed