SCHEMBL21112853

SCHEMBL21112853

COc1cccc(N2CCN(C(=O)[C@H]3OC(O)[C@H](O)[C@@H](O)[C@@H]3O)CC2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.51
▸ KMT2A Q03164 5/20 0.49
▸ MEN1 O00255 2/20 0.49
▸ CYP2C9 P11712 2/20 0.49
▸ CYP1A2 P05177 1/20 0.49
▸ CYP3A4 P08684 1/20 0.49
▸ CYP2C19 P33261 1/20 0.49
▸ MAPT P10636 2/20 0.48
▸ TP53 P04637 1/20 0.48
▸ CTSK P43235 1/20 0.48
▸ GAA P10253 2/20 0.48
▸ TDP1 Q9NUW8 1/20 0.48
▸ CA12 O43570 1/20 0.48
▸ CA1 P00915 1/20 0.48
▸ CA2 P00918 1/20 0.48
▸ CA9 Q16790 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ LIPE Q05469 1/20 0.46
▸ HDAC6 Q9UBN7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21113012 0.87 L3MBTL1 (0.58) ALDH1A1KMT2AMAPTGAASMN1; SMN2
SCHEMBL20873300 0.83 TFPI2 (0.54) ALDH1A1KMT2AMEN1CYP2C9CYP2C19
SCHEMBL21112897 0.78 ALDH1A1 (0.57) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL27739890 0.76 KMT2A (0.65) ALDH1A1KMT2AMEN1CYP2C9CYP1A2
SCHEMBL21112890 0.76 AKR1C3 (0.51) ALDH1A1KMT2AMEN1MAPTTP53
SCHEMBL21112919 0.76 MEN1 (0.54) ALDH1A1KMT2AMEN1MAPTSMN1; SMN2
SCHEMBL20873248 0.75 ALDH1A1 (0.47) ALDH1A1KMT2AMEN1CYP2C9CYP1A2
SCHEMBL4319359 0.75 KMT2A (0.63) ALDH1A1KMT2AMEN1CYP2C9CYP1A2
Hydrochloric Acid SCHEMBL27918226 0.75 KMT2A (0.63) ALDH1A1KMT2AMEN1CYP2C9CYP1A2
SCHEMBL8321177 0.75 KMT2A (0.63) ALDH1A1KMT2AMEN1CYP2C9CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210401946-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-20210401946-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-20210401947-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-20210401947-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein SANOFI (FR) 2021-08-17 — — US disclosed
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein SANOFI (FR) 2021-08-17 — — US disclosed
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2019-07-11 — — US disclosed
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2019-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein GPR119, SLC2A8, SLC2A4 ALDH1A1 1514/4885KMT2A 4658/4885MEN1 1610/4885
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 ALDH1A1 1514/4885KMT2A 4658/4885MEN1 1610/4885
US-20210401946-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 ALDH1A1 1514/4885KMT2A 4658/4885MEN1 1610/4885
US-20210401947-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 ALDH1A1 1514/4885KMT2A 4658/4885MEN1 1610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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