Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211083 | 1.00 | CTSK (0.35) | CTSKNOTUMPPARGPPARAABL1 | |
| SCHEMBL211156 | 0.95 | CTSK (0.34) | CTSKNOTUMABL1PKMMAPK1 | |
| SCHEMBL211648 | 0.94 | ABL1 (0.33) | ABL1 | |
| SCHEMBL214678 | 0.93 | CTSK (0.36) | CTSKNOTUMABL1PIN1KDM4E | |
| SCHEMBL212192 | 0.93 | CTSK (0.36) | CTSKNOTUMABL1PIN1KDM4E | |
| SCHEMBL211861 | 0.93 | CTSK (0.34) | CTSKNOTUMPPARGPPARAABL1 | |
| SCHEMBL210546 | 0.93 | CTSK (0.34) | CTSKNOTUMPPARGPPARAABL1 | |
| SCHEMBL215415 | 0.91 | CTSK (0.36) | CTSKNOTUMABL1PIN1ALDH1A1 | |
| SCHEMBL4346238 | 0.91 | CTSK (0.36) | CTSKNOTUMABL1PIN1ALDH1A1 | |
| SCHEMBL210485 | 0.90 | CTSK (0.36) | CTSKNOTUMABL1PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |