Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.42 |
| ▸ | EED | O75530 | 3/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.39 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21113387 | 0.86 | TBK1 (0.38) | TBK1RETTLR9TLR8TLR7 | |
| SCHEMBL21113418 | 0.85 | EED (0.35) | TBK1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21113226 | 0.84 | EED (0.44) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL29985806 | 0.83 | EED (0.51) | TBK1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21113266 | 0.81 | GPR119 (0.37) | TBK1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21113133 | 0.75 | EED (0.49) | TBK1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21113182 | 0.73 | EED (0.48) | TBK1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21113057 | 0.71 | TLR9 (0.33) | TBK1RETTLR9TLR8TLR7 | |
| SCHEMBL21113146 | 0.69 | EED (0.52) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL21113072 | 0.69 | EED (0.37) | EEDRBBP4SUZ12EZH2AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2021-04-06 | — | — | US | disclosed |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | HAIHE BIOPHARMA CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | EZH2, IKZF2, SUZ12 | TBK1 1192/4885EED 41/4885RBBP4 288/4885 |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | EZH2, IKZF2, SUZ12 | TBK1 1192/4885EED 41/4885RBBP4 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.