Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 5/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212597 | 0.93 | NOTUM (0.37) | ALDH1A1NOTUMCTSKNPC1SMN1; SMN2 | |
| SCHEMBL210077 | 0.87 | NOTUM (0.36) | ALDH1A1NOTUMCTSKHTTNPC1 | |
| SCHEMBL210644 | 0.86 | NOTUM (0.36) | ALDH1A1NOTUMCTSKNPC1CSNK1D | |
| SCHEMBL212116 | 0.86 | CTSK (0.36) | ALDH1A1NOTUMCTSKHTTSMN1; SMN2 | |
| SCHEMBL212590 | 0.85 | CTSK (0.36) | ALDH1A1NOTUMCTSKCSNK1DABL1 | |
| SCHEMBL210694 | 0.84 | NOTUM (0.34) | ALDH1A1NOTUMCTSKHTTSMN1; SMN2 | |
| SCHEMBL211462 | 0.84 | CTSK (0.36) | ALDH1A1NOTUMCTSKHTTSMN1; SMN2 | |
| SCHEMBL2722110 | 0.84 | ALDH1A1 (0.42) | ALDH1A1NOTUMCTSKHTTNPC1 | |
| SCHEMBL4353508 | 0.84 | CTSK (0.37) | ALDH1A1NOTUMCTSKNPC1CSNK1D | |
| SCHEMBL212341 | 0.83 | CTSK (0.37) | ALDH1A1NOTUMCTSKHTTCSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |