Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8280206 | 0.81 | DPP4 (0.50) | TRPA1GRM5ALOX5APFEN1PTGS1 | |
| SCHEMBL18014697 | 0.79 | CYP2A6 (0.47) | GRM5ALOX5APBRS3SCN9A | |
| SCHEMBL31359602 | 0.76 | HPGD (0.45) | GRM5ALOX5APFEN1BRS3PTGS1 | |
| SCHEMBL22548828 | 0.73 | KCNA5 (0.55) | PTGS2 | |
| SCHEMBL5336630 | 0.73 | DPP4 (0.54) | RIPK1 | |
| SCHEMBL12775791 | 0.72 | ATM (0.41) | RIPK1 | |
| SCHEMBL26040044 | 0.72 | PRMT5 (0.46) | PTGS1PTGS2 | |
| SCHEMBL10271458 | 0.71 | RAB9A (0.45) | — | |
| SCHEMBL9498645 | 0.71 | LMNA (0.38) | TRPA1PTGS1PTGS2OPRM1OPRK1 | |
| SCHEMBL19111144 | 0.70 | PIK3CA (0.33) | BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |