Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | IDH2 | P48735 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468072 | 0.86 | KMO (0.58) | CSNK1A1CSNK1DRPS6KA3KMOCLK1 | |
| SCHEMBL2944816 | 0.82 | CLK1 (0.60) | KMOCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL7996991 | 0.82 | CSNK1A1 (0.53) | CSNK1A1CSNK1DRPS6KA3AURKAAURKB | |
| SCHEMBL13273287 | 0.81 | KMO (0.62) | KMOCTSSPIK3CDPIK3CAPIK3CG | |
| SCHEMBL4738297 | 0.79 | PLK1 (0.68) | KMOCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL4737084 | 0.78 | SYK (0.62) | KMOCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL2788482 | 0.78 | CCNT1 (0.63) | KMODYRK1ACTSSPIK3CDPIK3CA | |
| SCHEMBL11469890 | 0.78 | KMO (0.62) | KMOCLK1CLK2DYRK1ACLK4 | |
| SCHEMBL5465537 | 0.77 | KMO (0.61) | KMOPIK3CDPIK3CAPIK3CGAURKA | |
| SCHEMBL5464931 | 0.77 | KMT2A (0.56) | KMOALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |