Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.60 |
| ▸ | KIT | P10721 | 5/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | ABL1 | P00519 | 12/20 | 0.57 |
| ▸ | RAF1 | P04049 | 2/20 | 0.56 |
| ▸ | ARAF | P10398 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 5/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | LDLR | P01130 | 2/20 | 0.51 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19966823 | 0.91 | BRAF (0.66) | BRAFMAPK14PDGFRAKITKDR | |
| SCHEMBL21116143 | 0.90 | BRAF (0.65) | BRAFMAPK14PDGFRAKITKDR | |
| SCHEMBL21074053 | 0.90 | BRAF (0.71) | BRAFMAPK14PDGFRAKITKDR | |
| SCHEMBL19966830 | 0.88 | BRAF (0.66) | BRAFMAPK14PDGFRAKITKDR | |
| SCHEMBL19966903 | 0.88 | BRAF (0.62) | BRAFMAPK14PDGFRAKITKDR | |
| SCHEMBL19966888 | 0.87 | BRAF (0.64) | BRAFMAPK14PDGFRAKITKDR | |
| SCHEMBL19966831 | 0.86 | ABL1 (0.62) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL4891507 | 0.84 | PDGFRA (0.63) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL19966913 | 0.83 | ABL1 (0.65) | BRAFMAPK14PDGFRAKITKDR | |
| SCHEMBL21074041 | 0.82 | BRAF (0.64) | BRAFMAPK14PDGFRAKITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | NATIONAL YANG-MING UNIVERSITY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | NATIONAL YANG-MING UNIVERSITY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | NATIONAL YANG-MING UNIVERSITY (TW) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | PRKAG1, PRKAG2, PRKAB1 | BRAF 1090/4885MAPK14 557/4885PDGFRA 844/4885 |
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | PRKAG1, PRKAG2, PRKAB1 | BRAF 1036/4885MAPK14 565/4885PDGFRA 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.