Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 17/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19926251 | 1.00 | ACKR3 (0.56) | ACKR3NAMPTDPP8DPP9DPP4 | |
| SCHEMBL30142472 | 1.00 | ACKR3 (0.56) | ACKR3NAMPTDPP8DPP9DPP4 | |
| SCHEMBL21116506 | 1.00 | ACKR3 (0.56) | ACKR3NAMPTDPP8DPP9DPP4 | |
| Hydrochloric Acid SCHEMBL19926194 | 0.99 | ACKR3 (0.55) | ACKR3NAMPTDPP8DPP9 | |
| SCHEMBL19925894 | 0.91 | ACKR3 (0.46) | ACKR3NAMPTDPP8DPP9 | |
| SCHEMBL29974582 | 0.91 | ACKR3 (0.53) | ACKR3NAMPT | |
| SCHEMBL19926160 | 0.91 | ACKR3 (0.53) | ACKR3NAMPT | |
| SCHEMBL19926202 | 0.90 | NAMPT (0.48) | ACKR3NAMPTDPP8DPP9 | |
| SCHEMBL30142463 | 0.90 | NAMPT (0.48) | ACKR3NAMPTDPP8DPP9 | |
| SCHEMBL19926258 | 0.90 | NAMPT (0.48) | ACKR3NAMPTDPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198685-B2 | Substituted ureas and methods of making and using same | MEBIAS DISCOVERY, INC. (US) | 2021-12-14 | — | — | US | disclosed |
| US-20200308155-A1 | Substituted Ureas and Methods of Making and Using Same | MEBIAS DISCOVERY, INC. | 2020-10-01 | — | — | US | disclosed |
| US-10683283-B2 | Substituted ureas and methods of making and using same | MEBIAS DISCOVERY, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-20190194178-A1 | SUBSTITUTED UREAS AND METHODS OF MAKING AND USING SAME | MEBIAS DISCOVERY LLC | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683283-B2 | Substituted ureas and methods of making and using same | UMPS, METTL3, UTS2R | ACKR3 2484/4885NAMPT 1872/4885DPP8 2925/4885 |
| US-20190194178-A1 | SUBSTITUTED UREAS AND METHODS OF MAKING AND USING SAME | UMPS, METTL3, UTS2R | ACKR3 2484/4885NAMPT 1872/4885DPP8 2925/4885 |
| US-11198685-B2 | Substituted ureas and methods of making and using same | UMPS, METTL3, UTS2R | ACKR3 2484/4885NAMPT 1872/4885DPP8 2925/4885 |
| US-20200308155-A1 | Substituted Ureas and Methods of Making and Using Same | UMPS, METTL3, UTS2R | ACKR3 2484/4885NAMPT 1872/4885DPP8 2925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.