SCHEMBL21117574

SCHEMBL21117574

COc1ccc2nccc(-c3nnc(NC4N=C(c5ccccc5)C5=CCCC=C5NC4=O)o3)c2c1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 7/20 0.39
FPR1 P21462 2/20 0.39
ELANE P08246 1/20 0.35
LMNA P02545 1/20 0.35
ALDH1A1 P00352 1/20 0.34
IDO1 P14902 4/20 0.33
BCL2 P10415 1/20 0.33
KDM4E B2RXH2 2/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
MAPK1 P28482 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
NR1I2 O75469 2/20 0.32
CCR8 P51685 1/20 0.32
NOTCH1 P46531 1/20 0.32
RBPJ Q06330 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20098380 0.86 CCKBR (0.41) FPR2FPR1ALDH1A1NOTCH1RBPJ
SCHEMBL20866958 0.86 CCKBR (0.41) FPR2FPR1ALDH1A1NOTCH1RBPJ
SCHEMBL21117290 0.78 FPR2 (0.38) FPR2FPR1
SCHEMBL24612309 0.76 CCKBR (0.40) ALDH1A1
SCHEMBL20098502 0.76 CCKBR (0.40) ALDH1A1
SCHEMBL24612281 0.76 CCKBR (0.46)
SCHEMBL21117152 0.73 CCKBR (0.34)
SCHEMBL24612275 0.73 CCKBR (0.50)
SCHEMBL20098425 0.73 CCKBR (0.50)
SCHEMBL21755266 0.72 CCKBR (0.43) FPR2FPR1ALDH1A1NOTCH1RBPJ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2021-01-05 US disclosed
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2019-06-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10881666-B2 Combination pharmaceutical agents as RSV inhibitors SERPINB1, FURIN, HIF1AN FPR2 154/4885FPR1 72/4885ELANE 321/4885
US-20190192535-A1 COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS SERPINB1, FURIN, HIF1AN FPR2 154/4885FPR1 72/4885ELANE 321/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.