Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19241750 | 0.87 | MAPT (0.42) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL22473985 | 0.85 | MAPT (0.44) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL27996129 | 0.85 | MAPT (0.42) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL25775949 | 0.81 | NPC1 (0.44) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL15501219 | 0.81 | HSF1 (0.39) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL9963730 | 0.78 | RAB9A (0.47) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL13767905 | 0.78 | RAB9A (0.47) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL86097 | 0.73 | MAPT (0.48) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL2147325 | 0.73 | MAPT (0.48) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL21348079 | 0.72 | TAAR1 (0.47) | MAPTNPC1RAB9ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3115362-B1 | PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONIST | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2019-06-12 | — | — | EP | disclosed |