Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19241750 | 0.98 | MAPT (0.42) | MAPTFAAHALDH1A1KMT2AHSD17B10 | |
| SCHEMBL27996129 | 0.94 | MAPT (0.42) | MAPTFAAHALDH1A1KMT2AHSD17B10 | |
| SCHEMBL25775949 | 0.88 | NPC1 (0.44) | MAPTFAAHALDH1A1HSD17B10CES1 | |
| SCHEMBL21118353 | 0.85 | MAPT (0.40) | MAPTALDH1A1HSD17B10TP53LMNA | |
| SCHEMBL18626325 | 0.82 | FAAH (0.47) | FAAH | |
| SCHEMBL13767905 | 0.81 | RAB9A (0.47) | MAPTALDH1A1TP53NPSR1LMNA | |
| SCHEMBL9963730 | 0.81 | RAB9A (0.47) | MAPTALDH1A1TP53NPSR1LMNA | |
| SCHEMBL15501219 | 0.81 | HSF1 (0.39) | MAPTALDH1A1HSD17B10TP53LMNA | |
| SCHEMBL28023594 | 0.79 | MAPT (0.42) | MAPTFAAHALDH1A1KMT2AHSD17B10 | |
| SCHEMBL29780557 | 0.79 | AAK1 (0.42) | MAPTALDH1A1KMT2AHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | QDPR, DPYD, DHPS | MAPT 1453/4885FAAH 900/4885ALDH1A1 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.