Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21348433 | 0.98 | LTA4H (0.37) | LTA4HKMT2AALDH1A1L3MBTL1HRH3 | |
| SCHEMBL25005825 | 0.96 | LTA4H (0.38) | LTA4HKMT2AALDH1A1L3MBTL1HRH3 | |
| SCHEMBL21348469 | 0.96 | LTA4H (0.33) | LTA4HKMT2AALDH1A1L3MBTL1HRH3 | |
| SCHEMBL22624141 | 0.92 | GNAO1 (0.35) | LTA4HKMT2AALDH1A1GNAO1GNAI3 | |
| SCHEMBL25006793 | 0.92 | HRH3 (0.31) | LTA4HHRH3TSHR | |
| SCHEMBL25696365 | 0.92 | GNAO1 (0.35) | LTA4HKMT2AALDH1A1GNAO1GNAI3 | |
| SCHEMBL25789578 | 0.90 | HRH3 (0.33) | LTA4HKMT2AALDH1A1L3MBTL1HRH3 | |
| SCHEMBL18476687 | 0.88 | HRH3 (0.31) | LTA4HHRH3TSHR | |
| SCHEMBL22648600 | 0.85 | GNAO1 (0.40) | ALDH1A1GNAO1GNAI3GNAI1 | |
| SCHEMBL24123133 | 0.83 | GNAO1 (0.42) | ALDH1A1L3MBTL1GNAO1GNAI3GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2019-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | LTA4H 1033/4885KMT2A 2283/4885ALDH1A1 3264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.