Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | KDM1B | Q8NB78 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29911221 | 1.00 | KDM1A (0.39) | KDM1AKDM1BKCNH2PIK3R1PIK3CA | |
| SCHEMBL29911222 | 0.81 | KDM1A (0.37) | KDM1AKDM1B | |
| SCHEMBL21129801 | 0.81 | KDM1A (0.37) | KDM1AKDM1B | |
| SCHEMBL31071314 | 0.81 | CYP1A2 (0.41) | KDM1AKDM1B | |
| SCHEMBL406362 | 0.79 | TDP1 (0.37) | KDM1AKDM1BKCNH2PIK3R1PIK3CA | |
| SCHEMBL13230128 | 0.78 | KMT2A (0.37) | — | |
| SCHEMBL9775902 | 0.76 | KEAP1 (0.56) | — | |
| SCHEMBL26931427 | 0.74 | KDM1A (0.33) | KDM1AKDM1B | |
| SCHEMBL30682774 | 0.74 | KDM1A (0.33) | KDM1AKDM1B | |
| SCHEMBL23544620 | 0.72 | NQO1 (0.37) | KDM1AKDM1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2024-04-09 | — | — | US | disclosed |
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| US-20210163486-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2021-06-03 | — | — | US | disclosed |
| US-20210163486-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2021-06-03 | — | — | US | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163486-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | KDM1A 41/4885KDM1B 36/4885KCNH2 3433/4885 |
| US-11952380-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | KDM1A 41/4885KDM1B 36/4885KCNH2 3433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.